专利名称：STEM CELLS TREATED BY IN VITRO
FUCOSYLATION AND METHODS OF USE
发明人：Lijun Xia,Rodger P. McEver申请号：US12707481申请日：20100217
公开号：US20100150883A1公开日：20100617
摘要：A method of in vitro fucosylation of selectin ligands on cord blood-derivedhematopoietic stem cells for bone marrow transplantation is disclosed. In this method,an effective amount of an α1,3-fucosyltransferase, e.g., α1,3-fucosyltransferase VI, is usedin vitro to treat cord blood-derived hematopoietic stem cells to convert non-functionalPSGL-1 or other ligands on the cell surface into functional forms that bind selectins,especially P-selectin or E-selectin. The treated cells have enhanced effectiveness inreconstituting bone marrow in patients in need of such therapy.
申请人：Lijun Xia,Rodger P. McEver
地址：Edmond OK US,Oklahoma City OK US
国籍：US,US
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