专利名称：Modulation of Tissue Transglutaminase
Activation in Disease
发明人：Thomas DiRaimondo,Xi Jin,Cornelius
Kloeck,Chaitan Khosla
申请号：US14126629申请日：20120619
公开号：US20140322278A1公开日：20141030
摘要：Compositions and methods are provided for modulating the physiologicalactivation of tissue transglutaminase (TG2); which methods can include inhibiting theactivation of TG2 associated with enteric inflammatory disorders, which disorders mayinclude celiac disease, irritable bowel syndrome, Crohn's Disease, dermatitis
herpetiformis, and the like. In other embodiments of the invention, methods are providedfor reducing undesirable paracellular transport in enteric tissues, in particular theparacellular transport of molecules greater than about 500 mw, e.g. peptides, includingwithout limitation immunogenic gluten peptides.
申请人：Thomas DiRaimondo,Xi Jin,Cornelius Kloeck,Chaitan Khosla
地址：Orinda CA US,Stanford CA US,Stanford CA US,Palo Alto CA US
国籍：US,US,US,US
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