LGD-4033_1165910-22-4_DataSheet_MedChemExpress

Product Data SheetProduct Name:CAS No.: CatNo:Cat. No.:MWt:Formula:Purity :LGD-40331165910-22-4HY-13981HY13981338.25C14H12F6N2O>98%Solubility:10mMinDMSO10 mM in DMSOMechanisms: Pathways:Others; Target:Androgen Receptor Biological Activity:LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of1 nM) and selectivity. IC50 value: 1 nM (Ki, for androgen receptor) Target: androgen receptor in vitro: LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, bindsandrogen receptor with high affinity and selectivity. in vivo: LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolicactivity in bone, and robust selectivity for muscle versus prostate In animal models. LGD-4033 iswelltoleratedhasalongeliminationhalflifeanddoseproportionalaccumulationuponmultiplewell tolerated, has a long elimination half-life and dose-proportional accumulation upon multipledosing. LGD-4033 is safe, has favorable pharmacokinetic profile, and increases lean body masseven during this short period without change in prostate-specific antigen....References:[1]. Basaria S,et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidaloral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci.2013 Jan;68(1):87-95. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com11DeerParkDrive, Suite 102D Monmouth Junction, NJ 08852,USAail: info@medchemexpress.com Web: www.medchemexpress.comEm