专利名称：MODIFIED POLYMERS FOR DELIVERY OF
POLYNUCLEOTIDES, METHOD OFMANUFACTURE, AND METHODS OF USETHEREOF
发明人：YURKOVETSKIY, Aleksandr,YIN,
Mao,LOWINGER, Timothy, B.,CABRAL,Carolina, B.,STEVENSON, Cheri,A.,HAMMOND, Charles, E.
申请号：EP11712741.5申请日：20110328公开号：EP2553019A1公开日：20130206
摘要：A polynucleotide delivery vehicle comprising a modified polymer is providedherein, the modified polymer having the following formula: in which W1, W2, W3, W4, W5,W6, Z1, Z2, Z3, Z4, Z5, Z9, R1, R2, R3, R4, R5, n1, n2, n3, n4, n5, and n6 are defined herein.Also disclosed are methods of delivering a polynucleotide to the cytoplasm of a selectedtissue type or cell type and methods of reducing expression of a gene in a cell or asubject in need thereof with the modified polymer.
申请人：Mersana Therapeutics, Inc.
地址：840 Memorial Drive Cambridge, MA 02139 US
国籍：US
代理机构：Rands, Peter David
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