专利名称：Cysteine protease inhibitors for use in
treatment of IGE mediated allergic diseases
发明人：Tony Johnson,Terrance Hart,Peter
Laing,Farouk Shakib,Martin Quibell
申请号：US09/000045申请日：19980226公开号：US06034066A公开日：20000307
摘要：The invention provides compounds for use in the treatment of allergic diseasesincluding juvenile asthma and eczema. The compounds can inhibit IgE mediated reactionto major environmental and occupational allergens and can also have a prophylacticeffect against allergic disease by preventing allergic sensitization to environmental andoccupational allergens when administered to at-risk individuals (e.g. , those at genetic riskof asthma and those exposed to occupational allergens in the workplace). The
compounds are also useful for inactivation or attenuation of the allergenicity of allergensin situ. The invention provides compounds and ligands per se, pharmaceutical
compositions containing the compounds, processes for producing the compounds andpharmaceutical compositions, and methods for using the compounds and compositions intreatment or prophylaxis of IgE mediated allergic diseases and in inactivation orattenuation of allergens in situ. The invention also enables the reduction or destructionof the viability of allergy-causing organisms.
申请人：PEPTIDE THERAPEUTICS LIMITED
代理机构：Nixon & Vanderhye
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