专利名称：TIOTROPIUM CONTAINING HFC SOLUTION
FORMULATIONS
发明人：SIX, Sabine,SCHMELZER, Christel,SCHMIDT,
Friedrich
申请号：EP03813106.6申请日：20031204公开号：EP1575588A1公开日：20050921
摘要：The present invention relates to the stabilization drug solution agent containingtiotropium, are suitable for aerosol administration. More specifically, the present
invention relates to the stabilization drug solution agent containing tiotropium, wherein itis suitable for aerosol administration inorganic acid or organic acid is added to aerosolsolution formulation and contains the preferred Tiotropium Bromide of tiotropium salt,in the solution using environmentally safe hydrofluoroalkane (HFC) as propellant andorganic compound as cosolvent. The acid, which provides, resists most of interaction drugthat degradation or decompose generates water and/or solution formulation present inthe drug and cosolvent.
申请人：Boehringer Ingelheim Pharma GmbH & Co.KG
地址：Binger Strasse 173 55216 Ingelheim am Rhein DE
国籍：DE
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