专利名称：METHODS OF SCREENING AND TREATMENT
WITH USP4 INHIBITORS
发明人：JACQ, Xavier,ROBINSON, Helen,OFIR-ROSENFELD, Yaara,JACKSON,
Stephen,WIJNHOVEN, Paul,NISHI, Ryotaro
申请号：EP16711012.1申请日：20160229公开号：EP3261674A1公开日：20180103
摘要：The present application relates to materials and methods for exploitingsynthetic lethality and/or chemo-sensitisation in DNA damage response (DDR) pathways.In particular, the application relates to ubiquitin hydrolase protein Ubiquitin SpecificProtease 4 (USP4) and its association with DDR pathways. Further, the use of USP4inhibitors in the treatment of cancer and methods of screening is described, in particular,use of inhibitors of USP4 in the treatment of tumours defective in double-strand breakrepair (DSBR) and/or tumours resistant to platinum-based chemotherapy, or to sensitise,i.e. chemosensitise or radiosensitise tumours to other therapeutic agents.
申请人：Mission Therapeutics Limited,Cambridge Enterprise Limited
地址：Babraham Research Campus Moneta (Building 280) Cambridge CB22 3ATGB,University of Cambridge The Old Schools Trinity Lane, Cambridge CB2 1TN GB
国籍：GB,GB
代理机构：Stratagem IPM Limited
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